5-Morpholinopyridin-3-amine → 5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline (75.0 mg, 0.20 mmol) and 5-morpholinopyridin-3-amine in toluene to give 5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.19 (1H, dd, J=7.9, 1.3 Hz), 7.89 (1H, d, J=2.3 Hz), 7.86 (1H, d, J=2.3 Hz), 7.78 (1H, td), 7.68 (1H, td, J=7.7, 1.2 Hz), 7.49 (1H, ddd, J=9.4, 2.4, 1.3 Hz), 7.42 (1H, dd, J=7.5, 1.3 Hz), 7.02-7.15 (2H, m), 6.55 (1H, t, J=2.3 Hz), 3.79 (4H, t, J=4.8 Hz), 3.09-3.22 (7H, m), 1.88 (3H, s). Mass Spectrum (ESI) m/e=511.1 (M+1).

Provenance & Evidence