5-Morpholinopyridin-3-amine → 5,7-difluoro-3-methyl-2-morpholino-N-(5-morpholinopyridin-3-yl)quinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)morpholine (40.0 mg, 0.130 mmol) and 5-morpholinopyridin-3-amine in toluene to give 5,7-difluoro-3-methyl-2-morpholino-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 7.93 (1H, d, J=2.3 Hz), 7.69 (1H, d, J=2.2 Hz), 7.31 (1H, ddd, J=10.1, 2.5, 1.3 Hz), 6.89 (1H, d, J=12.7 Hz), 6.80 (1H, ddd, J=13.9, 8.7, 2.6 Hz), 6.58 (1H, t, J=2.4 Hz), 3.79-3.94 (8H, m), 3.33-3.41 (4H, m), 3.16 (4H, dd, J=5.7, 3.9 Hz), 2.08 (3H, s). Mass Spectrum (ESI) m/e=442.1 (M+1).

Provenance & Evidence