4-(4-Chloro-5,7-difluoro-3-methylquinolin-2-yl)morpholine → N-(5-(3,6-dihydro-2H-pyran-4-yl)-pyridin-3-yl)-5,7-difluoro-3-methyl-2-morpholinoquinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)morpholine (40.0 mg, 0.130 mmol) and 5-(3,6-dihydro-2H-pyran-4-yl)pyridin-3-amine in toluene to give N-(5-(3,6-dihydro-2H-pyran-4-yl)-pyridin-3-yl)-5,7-difluoro-3-methyl-2-morpholinoquinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.28 (1H, d, J=2.0 Hz), 8.07 (1H, d, J=2.5 Hz), 7.32 (1H, ddd, J=10.0, 2.5, 1.4 Hz), 7.03 (1H, t, J=2.2 Hz), 6.94 (1H, d, J=12.7 Hz), 6.81 (1H, ddd, J=13.9, 8.6, 2.5 Hz), 6.11-6.19 (1H, m), 4.32 (2H, q, J=2.7 Hz), 3.93 (2H, t, J=5.5 Hz), 3.83-3.90 (4H, m), 3.34-3.43 (4H, m), 2.42-2.51 (2H, m), 2.06 (3H, s). Mass Spectrum (ESI) m/e=439.1 (M+1).

Provenance & Evidence