4-Chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline → 5,7-difluoro-N-(6'-methoxy-5-morpholino-2,3'-bipyridin-3-yl)-3-methyl-2-(2-(methylsulfonyl)-phenyl)quinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)phenyl)quinoline (50.0 mg, 0.140 mmol) and 6′-methoxy-5-morpholino-2,3′-bipyridin-3-amine in toluene to give 5,7-difluoro-N-(6′-methoxy-5-morpholino-2,3′-bipyridin-3-yl)-3-methyl-2-(2-(methylsulfonyl)-phenyl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.64 (1H, d, J=1.8 Hz), 8.20 (1H, d, J=7.2 Hz), 8.00 (1H, dd, J=8.5, 2.4 Hz), 7.94 (1H, br. s.), 7.80 (1H, td, J=7.5, 1.4 Hz), 7.70 (1H, td, J=7.7, 1.4 Hz), 7.47 (1H, ddd, J=9.4, 2.4, 1.3 Hz), 7.42 (1H, d, J=7.2 Hz), 6.92-7.04 (2H, m), 6.88 (1H, dd, J=8.6, 0.8 Hz), 6.53 (1H, br. s.), 4.00 (3H, s), 3.78 (4H, t, J=4.7 Hz), 3.02-3.27 (7H, m), 1.97 (3H, s). Mass Spectrum (ESI) m/e=618.2 (M+1).

Provenance & Evidence