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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1431622Generated: November 1, 2026

5-Fluoro-2-(methylthio)phenylboronic acid → 4-Chloro-5,7-difluoro-2-(5-fluoro-2-(methylthio)phenyl)-3-methylquinoline

https://huagongshe.com/reaction/1431622

Reaction equation

Participants

RoleNameHCIDCharge
Reactant5-Fluoro-2-(methylthio)phenylboronic acidHCID 53216369—
Reactant2,4-Dichloro-5,7-difluoro-3-methylquinolineHCID 59631040—
Product4-Chloro-5,7-difluoro-2-(5-fluoro-2-(methylthio)phenyl)-3-methylquinolineHCID 59631178—

Reaction Steps

Essentially prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (270 mg, 1.10 mmol) and 5-fluoro-2-(methylthio)phenylboronic acid to give 4-chloro-5,7-difluoro-2-(5-fluoro-2-(methylthio)phenyl)-3-methylquinoline. Mass Spectrum (ESI) m/e=354.1 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08940724B2
Source datasetuspto-grants-2015_01
ORD IDord-1c609b277b64411fb95d6619e6527530
Source noteuspto-grants-2015_01