[2-(Methylsulfanyl)-5-(trifluoromethoxy)phenyl]boronic acid → HCID 59631118, compound

HRID 1431628Notes

Reaction equation

HRID 1431628 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[CH3:16][S:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][C:25]([F:28])([F:27])[F:26])=[CH:20][C:19]=1B(O)O>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:19]2[CH:20]=[C:21]([O:24][C:25]([F:27])([F:28])[F:26])[CH:22]=[CH:23][C:18]=2[S:17][CH3:16])[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 44717722[2-(Methylsulfanyl)-5-(trifluoromethoxy)phenyl]boronic acidHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 59631118HCID 59631118, compound

Procedure

Essentially prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (400 mg, 1.60 mmol) and 2-(methylthio)-5-(trifluoromethoxy)-phenylboronic acid to give 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylthio)-5-(trifluoromethoxy)phenyl)quinoline. Mass Spectrum (ESI) m/e=420.0 (M+1).

Workup

  1. customEssentially prepared

Sources & evidence

ORD record
ord-c9cba4382dca466382f7543f57615be4
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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