5-Morpholinopyridin-3-amine → HCID 67507715, compound

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)-5-(trifluoromethoxy)phenyl)quinoline (50.0 mg, 0.11 mmol) and 5-morpholinopyridin-3-amine in toluene to give 5,7-difluoro-3-methyl-2-(2-(methylsulfonyl)-5-(trifluoromethoxy)phenyl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.25 (1H, d, J=8.8 Hz), 7.91 (1H, d, J=2.3 Hz), 7.87 (1H, d, J=2.3 Hz), 7.44-7.54 (2H, m), 7.25 (1H, d, J=1.6 Hz), 7.20 (1H, d, J=14.5 Hz), 7.10 (1H, ddd, J=13.9, 8.6, 2.5 Hz), 6.54 (1H, t, J=2.3 Hz), 3.79 (4H, t, J=4.8 Hz), 3.07-3.22 (7H, m), 1.89 (3H, s). Mass Spectrum (ESI) m/e=595.2 (M+1).

Provenance & Evidence