5-Morpholinopyridin-3-amine → 7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-chloro-7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methylquinoline (26.0 mg, 0.078 mmol) and 5-morpholinopyridin-3-amine in toluene to give 7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.58 (1H, dd, J=6.2, 2.8 Hz), 8.39 (1H, ddd, J=9.1, 4.4, 2.9 Hz), 8.11 (1H, br. s.), 8.03 (1H, dd, J=9.4, 5.9 Hz), 7.78 (2H, dd, J=9.8, 2.5 Hz), 7.64 (1H, br. s.), 7.29-7.42 (2H, m), 6.44 (1H, t, J=2.2 Hz), 3.77-3.87 (4H, m), 3.04-3.19 (4H, m), 2.19 (3H, d, J=2.3 Hz). Mass Spectrum (ESI) m/e=478.1 (M+1).

Provenance & Evidence