HRID1431633
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Essentially prepared according to Procedure H using 4-chloro-7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methylquinoline (150.0 mg, 0.45 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-dimorpholinopyridin-3-yl)-7-fluoro-2-(2-fluoro-5-nitrophenyl)-3-methylquinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.58 (1H, dd, J=6.2, 2.8 Hz), 8.39 (1H, ddd, J=9.0, 4.3, 2.9 Hz), 7.89 (1H, dd, J=9.0, 5.9 Hz), 7.79 (1H, dd, J=9.8, 2.5 Hz), 7.64 (1H, d, J=2.7 Hz), 7.32-7.44 (2H, m), 6.90 (1H, br. s.), 6.26 (1H, d, J=1.2 Hz), 3.94 (4H, t, J=4.6 Hz), 3.69-3.85 (4H, m), 3.13-3.32 (4H, m), 2.90-3.03 (4H, m), 2.19 (3H, d, J=2.0 Hz). Mass Spectrum (ESI) m/e=563.3 (M+1).
WORKUP
后处理
- customEssentially prepared