5-Morpholinopyridin-3-amine → 5,7-difluoro-3-methyl-2-(2-(methylsulfinyl)phenyl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using (+/−)-4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfinyl)phenyl)quinoline (30.0 mg, 0.085 mmol) and 5-morpholinopyridin-3-amine in toluene to give 5,7-difluoro-3-methyl-2-(2-(methylsulfinyl)phenyl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.22 (1H, dd, J=7.9, 1.1 Hz), 7.96 (1H, d, J=2.3 Hz), 7.81 (1H, d, J=2.2 Hz), 7.73 (1H, td, J=7.7, 1.3 Hz), 7.63 (1H, td, J=7.5, 1.3 Hz), 7.50 (1H, ddd, J=9.2, 2.5, 1.4 Hz), 7.39 (1H, dd, J=7.6, 1.2 Hz), 7.20 (1H, d, J=14.1 Hz), 7.08 (1H, ddd, J=13.9, 8.4, 2.5 Hz), 6.60 (1H, t, J=2.2 Hz), 3.80-3.93 (4H, m), 3.12-3.28 (4H, m), 2.87 (3H, s), 1.98 (3H, s). Mass Spectrum (ESI) m/e=495.2 (M+1).

Provenance & Evidence