2,5-Dimorpholinopyridin-3-amine → (+/-)-N-(2,5-dimorpholinopyridin-3-yl)-5,7-difluoro-3-methyl-2-(2-(methylsulfinyl)phenyl)quinolin-4-amine

Participants

Reaction Steps

Essentially prepared according to Procedure H using (+/−)-4-chloro-5,7-difluoro-3-methyl-2-(2-(methylsulfinyl)phenyl)quinoline (22.0 mg, 0.063 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give (+/−)-N-(2,5-dimorpholinopyridin-3-yl)-5,7-difluoro-3-methyl-2-(2-(methylsulfinyl)phenyl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.21 (1H, d, J=8.0 Hz), 7.91 (1H, br. s.), 7.76 (1H, td, J=7.6, 1.4 Hz), 7.66-7.71 (1H, m), 7.65 (1H, d, J=2.5 Hz), 7.54 (1H, d, J=8.6 Hz), 7.39 (1H, d, J=7.6 Hz), 7.08 (1H, ddd, J=13.5, 8.5, 2.4 Hz), 6.38 (1H, br. s.), 3.92 (4H, br. s.), 3.84 (4H, t, J=4.8 Hz), 3.19-3.54 (3H, m), 3.00-3.18 (5H, m), 2.55-2.97 (3H, m), 2.01 (3H, br. s.). Mass Spectrum (ESI) m/e=580.3 (M+1).

Provenance & Evidence