2,4-Dichloro-5,7-difluoro-3-methylquinoline → HCID 59631382, compound

HRID 1431641Notes

Reaction equation

HRID 1431641 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[CH3:16][C:17]1[CH:18]=[CH:19][C:20]([S:26][CH3:27])=[C:21](B(O)O)[CH:22]=1>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:19]2[CH:18]=[C:17]([CH3:16])[CH:22]=[CH:21][C:20]=2[S:26][CH3:27])[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinolineHCID 59631451HCID 59631451, compound

Product 1

HCID 59631382HCID 59631382, compound

Procedure

Essentially prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (130 mg, 0.51 mmol) and 5-methyl-2-(methylthio)phenylboronic acid to give 4-chloro-5,7-difluoro-3-methyl-2-(5-methyl-2-(methylthio)phenyl)-quinoline. Mass Spectrum (ESI) m/e=350.0 (M+1).

Workup

  1. customEssentially prepared

Sources & evidence

ORD record
ord-95ac1f019ad241d0adec79a3b18ae701
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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