5-Morpholinopyridin-3-amine → HCID 59631469, compound

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(5-methyl-2-(methylsulfonyl)phenyl)quinoline (60.0 mg, 0.16 mmol) and 5-morpholinopyridin-3-amine in toluene to give 5,7-difluoro-3-methyl-2-(5-methyl-2-(methylsulfonyl)phenyl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.05 (1H, d, J=8.0 Hz), 7.83-7.92 (2H, m), 7.44-7.52 (2H, m), 7.00-7.24 (3H, m), 6.54-6.59 (1H, m), 3.79 (3H, t, J=4.9 Hz), 3.09-3.25 (4H, m), 3.07 (2H, s), 2.50 (2H, s), 2.04 (1H, s), 1.89 (3H, s), 1.26 (2H, t, J=7.1 Hz). Mass Spectrum (ESI) m/e=525.3 (M+1).

Provenance & Evidence