2,5-Dimorpholinopyridin-3-amine → HCID 59631528, compound

Participants

Reaction Steps

Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(5-methyl-2-(methylsulfonyl)phenyl)quinoline (50.0 mg, 0.13 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give N-(2,5-dimorpholinopyridin-3-yl)-5,7-difluoro-3-methyl-2-(5-methyl-2-(methylsulfonyl)phenyl)-quinolin-4-amine. 1H NMR (CDCl3) δ ppm 8.07 (1H, d, J=8.0 Hz), 7.83 (1H, d, J=12.5 Hz), 7.42-7.58 (3H, m), 7.21 (1H, br. s.), 7.05 (1H, ddd, J=13.6, 8.6, 2.6 Hz), 6.53 (1H, br. s.), 3.84-4.04 (4H, m), 3.78 (4H, d, J=4.3 Hz), 3.41 (2H, br. s.), 2.85-3.21 (9H, m), 2.50 (3H, s), 1.93 (3H, s). Mass Spectrum (ESI) m/e=610.3 (M+1).

Provenance & Evidence