Trifluoroacetic acid → 4-Chloro-5,7-difluoro-3-methyl-2-(piperazin-1-yl)quinoline 2,2,2-trifluoroacetate

Participants

Reaction Conditions

Reaction Steps

The tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate (370 mg, 0.93 mmol) was dissolved in dichloromethane (3.0 mL) and cooled to 0° C. The trifluoroacetic acid (0.50 mL, 6.5 mmol) was added and the mixture was stirred for 2 h while warming to rt. The mixture was then cond and triturated with EtOAc. The slurry was filtered to give 4-chloro-5,7-difluoro-3-methyl-2-(piperazin-1-yl)quinoline 2,2,2-trifluoroacetate. Mass Spectrum (ESI) m/e=298.1 (M+1).

Provenance & Evidence