HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodobenzene → 4-Chloro-5,7-difluoro-3-methyl-2-(4-phenylpiperazin-1-yl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | 4-Chloro-5,7-difluoro-3-methyl-2-(piperazin-1-yl)quinoline 2,2,2-trifluoroacetate | HCID 86649511 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 4-Chloro-5,7-difluoro-3-methyl-2-(4-phenylpiperazin-1-yl)quinoline | HCID 59631467 | — |
Reaction Steps
Essentially prepared according to Procedure H using 4-chloro-5,7-difluoro-3-methyl-2-(piperazin-1-yl)quinoline 2,2,2-trifluoroacetate (75.0 mg, 0.18 mmol) and iodobenzene (1.0 eq of triethylamine added to account for TFA salt) in toluene to give 4-chloro-5,7-difluoro-3-methyl-2-(4-phenylpiperazin-1-yl)-quinoline. Mass Spectrum (ESI) m/e=374.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-f351e9bad57d46e5b5c30d867200720b |
| Source note | uspto-grants-2015_01 |