HRID1431651
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
AUXILIARIES
试剂、催化剂与溶剂
PROCEDURE
实验过程
Essentially prepared according to Procedure H using tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate (240.0 mg, 0.60 mmol) and 2,5-dimorpholinopyridin-3-amine in toluene to give tert-butyl 4-(4-(2,5-dimorpholinopyridin-3-ylamino)-5,7-difluoro-3-methylquinolin-2-yl)piperazine-1-carboxylate. 1H NMR (CDCl3) δ ppm 7.62 (1H, d, J=2.7 Hz), 7.57 (1H, d, J=11.2 Hz), 7.31 (1H, d, J=7.6 Hz), 6.80 (1H, ddd, J=13.4, 8.8, 2.5 Hz), 6.25 (1H, d, J=2.5 Hz), 3.88-3.94 (4H, m), 3.72-3.83 (4H, m), 3.62 (4H, br. s.), 3.36 (4H, br. s.), 3.15 (4H, br. s.), 2.90-3.04 (4H, m), 2.11 (3H, s), 1.48-1.56 (9H, m). Mass Spectrum (ESI) m/e=626.3 (M+1).
WORKUP
后处理
- customEssentially prepared