2,4-Dichloro-5,7-difluoro-3-methylquinoline → HCID 59631111, compound

HRID 1431653Notes

Reaction equation

HRID 1431653 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[CH3:16][S:17][C:18]1[CH:23]=[CH:22][C:21]([C:24](=[O:26])[CH3:25])=[CH:20][C:19]=1B1OC(C)(C)C(C)(C)O1>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:23]2[CH:22]=[C:21]([C:24](=[O:26])[CH3:25])[CH:20]=[CH:19][C:18]=2[S:17][CH3:16])[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinolineHCID 59631337HCID 59631337, compound

Product 1

HCID 59631111HCID 59631111, compound

Procedure

Essentially prepared according to Procedure F using 2,4-dichloro-5,7-difluoro-3-methylquinoline (150 mg, 0.59 mmol) and 1-(4-(methylthio)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethanone to give 1-(3-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-4-(methylthio)phenyl)ethanone. Mass Spectrum (ESI) m/e=378.1 (M+1).

Workup

  1. customEssentially prepared

Sources & evidence

ORD record
ord-6f5a418a2fd54c589ddf1c31151af71b
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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