5-Morpholinopyridin-3-amine → HCID 50906986, compound

Participants

Reaction Steps

Essentially prepared according to Procedure H using 1-(3-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-4-(methylsulfonyl)phenyl)ethanone (150.0 mg, 0.35 mmol) and 5-morpholinopyridin-3-amine in toluene to give 1-(3-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)-4-(methylsulfonyl)-phenyl)ethanone. 1H NMR (CDCl3) δ ppm 8.17-8.35 (3H, m), 7.94-8.13 (2H, m), 7.76 (1H, s), 7.54-7.66 (1H, m), 7.17 (1H, ddd, J=13.0, 8.5, 2.4 Hz), 6.73 (1H, s), 3.72-3.88 (4H, m), 3.18-3.33 (4H, m), 3.10 (3H, s), 2.70 (3H, s), 1.96 (3H, s). Mass Spectrum (ESI) m/e=553.2 (M+1).

Provenance & Evidence