tert-Butyl (2S)-2-methylpiperazine-1-carboxylate → HCID 59631133, compound

HRID 1431663Notes

Reaction equation

HRID 1431663 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[CH3:16][C@H:17]1[CH2:22][NH:21][CH2:20][CH2:19][N:18]1[C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24]>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([N:21]2[CH2:20][CH2:19][N:18]([C:23]([O:25][C:26]([CH3:29])([CH3:28])[CH3:27])=[O:24])[C@@H:17]([CH3:16])[CH2:22]2)[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 10081508tert-Butyl (2S)-2-methylpiperazine-1-carboxylateHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 59631133HCID 59631133, compound

Procedure

Essentially prepared according to Procedure G using 2,4-dichloro-5,7-difluoro-3-methylquinoline (1.00 g, 4.10 mmol) and (S)-tert-butyl 2-methylpiperazine-1-carboxylate to give (S)-tert-butyl 4-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-2-methylpiperazine-1-carboxylate. Mass Spectrum (ESI) m/e=412.3 (M+1).

Workup

  1. customEssentially prepared

Sources & evidence

ORD record
ord-39eed7f69b95424c917e857f2943d6c6
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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