Methanesulfonyl chloride → HCID 59631559, compound

Participants

Reaction Steps

Essentially prepared according to Procedure M using (S)-5,7-difluoro-3-methyl-2-(3-methylpiperazin-1-yl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine (50 mg, 0.11 mmol) and methylsulfonyl chloride to give (S)-5,7-difluoro-3-methyl-2-(3-methyl-4-(methylsulfonyl)piperazin-1-yl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 7.95 (1H, d, J=2.5 Hz), 7.66 (1H, d, J=2.3 Hz), 7.30 (1H, ddd, J=9.9, 2.5, 1.3 Hz), 6.92 (1H, d, J=13.3 Hz), 6.83 (1H, ddd, J=13.9, 8.7, 2.6 Hz), 6.60 (1H, t, J=2.3 Hz), 4.15-4.28 (1H, m), 3.86 (4H, dd, J=5.7, 4.1 Hz), 3.65-3.80 (2H, m), 3.58 (1H, dt, J=12.9, 1.9 Hz), 3.51 (1H, td, J=12.3, 2.9 Hz), 3.22 (1H, dd, J=12.9, 3.5 Hz), 3.13-3.19 (4H, m), 3.06 (1H, td, J=12.3, 3.2 Hz), 2.93 (3H, s), 2.09 (3H, s), 1.41 (3H, d, J=6.8 Hz). Mass Spectrum (ESI) m/e=533.2 (M+1).

Provenance & Evidence