Isopropyl chloroformate → Isopropyl 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazine-1-carboxylate

Participants

Reaction Steps

Prepared according to Procedure N using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and isopropyl chloroformate to give isopropyl 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazine-1-carboxylate. 1H NMR (DMSO-d6) δ ppm 1.14-1.22 (m, 6H), 2.09 (br s, 3H), 3.05 (t, J=4.4 Hz, 4H), 3.27-3.31 (m, 4H), 3.54 (br s, 4H), 3.69 (t, J=4.4 Hz, 4H), 4.81 (m, 1H) 6.49 (br s, 1H), 7.13-7.18 (m, 1H), 7.29 (d, J=5.2 Hz, 1H), 7.52 (d, J=1.6 Hz, 1H), 7.78 (d, J=2 Hz, 1H), 8.34 (s, 1H). Mass Spectrum (ESI) m/e=527.3 (M+1).

Provenance & Evidence