Ethyl chloroformate → Ethyl 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazine-1-carboxylate

Participants

Reaction Steps

Prepared according to Procedure N using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and ethyl chloroformate to give ethyl 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazine-1-carboxylate. 1H NMR (DMSO-d6) δ ppm 1.09 (t, J=7.2 Hz, 3H), 2.13 (s, 3H), 3.04-3.06 (m, 4H), 3.27 (s, 4H), 3.55 (s, 4H), 3.68-3.70 (m, 4H), 4.08 (q, J=6.8 Hz, 2H,), 6.49 (m, 1H), 7.14-7.20 (m, 1H), 7.29 (dd, J=9.8 Hz, J=2 Hz, 1H), 7.52 (d, J=1.6 Hz, 1H), 7.78 (d, J=2 Hz, 1H), 8.38 (s, 1H). Mass Spectrum (ESI) m/e=513.1 (M+1).

Provenance & Evidence