2-Fluorobenzenesulphonyl chloride → HCID 59631588, compound

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Reaction Steps

Prepared according to Procedure M using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and 2-fluorobenzene-1-sulfonyl chloride to give 5,7-difluoro-2-(4-(2-fluorophenylsulfonyl)-piperazin-1-yl)-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (DMSO-d6) δ ppm 2.00 (br s, 3H), 3.04 (t, J=4.4 Hz, 4H), 3.26 (br s, 4H), 3.33-3.37 (m, 4H), 3.68 (t, J=4.0 Hz, 4H), 6.48 (s, 1H), 7.14-7.19 (m, 1H), 7.26-7.29 (m, 1H), 7.45-7.54 (m, 3H), 7.77 (d, J=2.4 Hz, 2H), 7.81-7.85 (m, 1H), 8.35 (s, 1H). Mass Spectrum (ESI) m/e=599.4 (M+1).

Provenance & Evidence