3-Fluorobenzenesulfonyl Chloride → HCID 59631444, compound

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Prepared according to Procedure M using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and 3-fluorobenzene-1-sulfonyl chloride to give 5,7-difluoro-2-(4-(3-fluorophenylsulfonyl)-piperazin-1-yl)-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (DMSO-d6) δ ppm 1.96 (br s, 3H), 3.03 (t, J=4.4 Hz, 4H), 3.14 (br s, 4H), 3.34-3.36 (m, 4H), 3.68 (t, J=4.4 Hz, 4H), 6.47 (s, 1H), 7.13-7.19 (m, 1H), 7.25-7.28 (m, 1H), 7.49 (d, J=2.0 Hz, 1H), 7.60-7.65 (m, 3H), 7.71-7.77 (m, 2H,), 8.36 (s, 1H). Mass Spectrum (ESI) m/e=599.4 (M+1).

Provenance & Evidence