4-Fluorobenzenesulfonyl chloride → HCID 59631470, compound

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Reaction Steps

Prepared according to Procedure M using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and 4-fluorobenzene-1-sulfonyl chloride to give 5,7-difluoro-2-(4-(4-fluorophenylsulfonyl)-piperazin-1-yl)-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (DMSO-d6) δ ppm 1.97 (br s, 3H), 3.04 (t, J=4.8 Hz, 4H), 3.11 (br s, 4H), 3.33-3.37 (m, 4H), 3.69 (t, J=4.4 Hz, 4H), 6.48 (s, 1H), 7.13-7.19 (m, 1H), 7.25-7.28 (m, 1H), 7.49-7.54 (m, 3H), 7.77 (d, J=2.0 Hz, 1H), 7.84-7.88 (m, 2H,), 8.34 (s, 1H). Mass Spectrum (ESI) m/e=599.4 (M+1).

Provenance & Evidence