Pyridine-3-sulfonyl chloride → HCID 59631124, compound

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Reaction Steps

Prepared according to Procedure M using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and pyridine-3-sulfonyl chloride to give 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(4-(pyridin-3-ylsulfonyl)piperazin-1-yl)quinolin-4-amine. 1H NMR (DMSO-d6) δ ppm 1.98 (d, J=6.0 Hz, 3H), 3.04 (t, J=4.8 Hz, 4H), 3.18 (br s, 4H), 3.33-3.37 (m, 4H), 3.69 (t, J=4.4 Hz, 4H), 6.48 (s, 1H), 7.13-7.19 (m, 1H), 7.25-7.28 (m, 1H), 7.50 (d, J=2.0 Hz, 1H), 7.70-7.77 (m, 1H), 7.77 (d, J=2.0 Hz, 1H,), 8.19-8.22 (m, 1H), 8.34 (s, 1H), 8.90-8.91 (m, 1H), 8.95 (d, J=2.4 Hz, 1H). Mass Spectrum (ESI) m/e=582.4 (M+1).

Provenance & Evidence