Isobutyl chloroformate → HCID 57449775, compound

Participants

Reaction Steps

Prepared according to Procedure N using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50 mg, 0.11 mmol) and isobutyl chloroformate to give isobutyl 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazine-1-carboxylate. 1H NMR (DMSO-d6) δ ppm 0.86-0.92 (m, 6H), 1.86-1.91 (m, 1H), 2.09 (br s, 3H), 3.05 (t, J=4.4 Hz, 4H), 3.28-3.32 (m, 4H), 3.57 (br s, 4H), 3.69 (t, J=4.4 Hz, 4H), 3.83 (d, J=6.4 Hz, 2H), 6.50 (s, 1H), 7.13-7.19 (m, 1H), 7.28-7.32 (m, 1H), 7.517 (s, 1H), 7.78 (d, J=2 Hz, 1H), 8.36 (s, 1H). Mass Spectrum (ESI) m/e=541.4 (M+1).

Provenance & Evidence