Cyclopentanecarbonyl chloride → HCID 59631243, compound

Participants

Reaction Steps

Prepared according to Procedure R using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (40.0 mg, 0.09 mmol) and cyclopentanecarbonyl chloride to give cyclopentyl(4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)methanone. 1H NMR (DMSO-d6) δ ppm 1.51-1.73 (m, 8H), 2.10 (br s, 3H), 3.00 (m, 1H), 3.00-3.07 (m, 4H), 3.24 (br s, 2H), 3.33 (br s, 4H), 3.65-3.70 (m, 6H), 6.51 (br s, 1H), 7.13-7.19 (m, 1H), 7.27-7.30 (m, 1H), 7.52 (d, J=2.0 Hz, 1H), 7.78 (d, J=2.4 Hz, 1H), 8.37 (s, 1H). Mass Spectrum (ESI) m/e=537.4 (M+1).

Provenance & Evidence