1-Propanesulfonyl chloride, 2-methyl- → HCID 59631050, compound

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Reaction Steps

Prepared according to Procedure M using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50.0 mg, 0.11 mmol) and isobutylsulfonyl chloride to give 5,7-difluoro-2-(4-(isobutylsulfonyl)piperazin-1-yl)-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (DMSO-d6) δ ppm 1.05 (d, J=6.8 Hz, 6H), 2.11 (br s, 3H), 2.12-2.16 (m, 1H) 2.96 (d, J=6.8 Hz, 2H), 3.06 (br s, 4H), 3.33-3.37 (m, 8H), 3.69 (t, J=9.2 Hz, 4H), 6.53 (s, 1H), 7.16-7.20 (m, 1H), 7.29-7.32 (m, 1H), 7.52 (s, 1H), 7.79 (s, 1H,), 8.41 (s, 1H). Mass Spectrum (ESI) m/e=561.4 (M+1).

Provenance & Evidence