Isopropyl isocyanate → HCID 57449782, compound

Participants

Reaction Steps

Prepared according to Procedure P using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50.0 mg, 0.11 mmol) and isopropylisocyanate to give 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)-N-isopropylpiperazine-1-carboxamide. 1H NMR (DMSO-d6) δ ppm 1.07 (d, J=6.8 Hz, 6H), 2.08 (br s, 3H), 3.04-3.06 (m, 4H), 3.24 (br s, 4H), 3.46-3.50 (m, 4H), 3.68-3.70 (m, 4H), 3.78 (m, 1H), 6.26 (d, J=7.6 Hz, 1H), 6.49 (br s, 1H), 7.12-7.18 (m, 1H), 7.28-7.32 (m, 1H), 7.53 (s, 1H), 7.78 (d, J=2 Hz, 1H), 8.35 (s, 1H). Mass Spectrum (ESI) m/e=526.4 (M+1).

Provenance & Evidence