Cyclopentanesulfonyl chloride → HCID 59631027, compound

Participants

Reaction Steps

Prepared according to Procedure M using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50.0 mg, 0.11 mmol) and cyclopentylsulfonyl chloride to give 2-(4-(cyclopentylsulfonyl)piperazin-1-yl)-5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)quinolin-4-amine. 1H NMR (CDCl3) δ ppm 1.54-1.58 (m, 2H), 1.67 (s, 2H), 1.80-1.85 (m, 2H), 1.96-1.99 (m, 2H), 2.08 (s, 3H), 3.05 (t, J=4.4 Hz, 4H), 3.33 (s, 4H), 3.39 (t, J=4.8 Hz, 4H), 3.69 (t, J=3.6 Hz, 5H), 6.51 (s, 1H), 7.15-7.20 (m, 1H), 7.30 (d, J=11.2 Hz, 1H), 7.52 (s, 1H), 7.78 (s, 1H), 8.37 (s, 1H). Mass Spectrum (ESI) m/e=573.1 (M+1).

Provenance & Evidence