Pyrimidine-2-carboxylic acid → HCID 67507914, compound

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Reaction Steps

Prepared according to Procedure Q using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (40.0 mg, 0.09 mmol) and pyrimidine-2-carboxylic acid to give (4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)(pyrimidin-2-yl)methanone. 1H NMR (DMSO-d6) δ ppm 2.09 (br s, 3H), 3.04 (m, 4H), 3.28-3.29 (m, 2H), 3.33-3.40 (m, 4H), 3.68 (m, 4H), 3.86 (m, 2H), 6.50 (s, 1H), 7.14-7.20 (m, 1H), 7.29-7.30 (m, 1H), 7.52 (s, 1H), 7.63 (t, J=4.8 Hz, 1H), 7.78 (br s, 1H), 8.37 (s, 1H), 8.93 (d, J=5.2 Hz, 2H). Mass Spectrum (ESI) m/e=546.9 (M+1).

Provenance & Evidence