4-Pyrimidinecarboxylic acid → HCID 59631122, compound

Participants

Reaction Steps

Prepared according to Procedure Q using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (40.0 mg, 0.09 mmol) and pyrimidine-4-carboxylic acid to give (4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)(pyrimidin-4-yl)methanone. 1H NMR (DMSO-d6) δ ppm 2.10 (br s, 3H), 3.05 (t, J=4.4 Hz, 4H), 3.30-3.35 (m, 2H), 3.36-3.40 (m, 2H), 3.53-3.56 (m, 2H), 3.67-3.69 (m, 4H), 3.84-3.86 (m, 2H), 6.51 (s, 1H), 7.14-7.19 (m, 1H), 7.28-7.31 (m, 1H), 7.51 (s, 1H), 7.74 (d, J=5.2 Hz, 1H), 7.78 (d, J=3.2 Hz, 1H), 8.37 (s, 1H), 9.00 (d, J=5.2 Hz, 1H), 9.28 (s, 1H). Mass Spectrum (ESI) m/e=546.9 (M+1).

Provenance & Evidence