5-Methylfuran-2-carbonyl chloride → HCID 59631242, compound

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Reaction Steps

Prepared according to Procedure R using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50.0 mg, 0.11 mmol) and 5-methylfuran-2-carbonyl chloride to give (4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)(5-methylfuran-2-yl)methanone. 1H NMR (CDCl3) δ ppm 2.11 (br s, 3H), 2.49 (br s, 3H), 3.06 (t, J=5.6 Hz, 4H), 3.30-3.40 (m, 4H), 3.69 (t, J=5.6 Hz, 4H), 3.86 (br s, 4H), 6.27 (br s, 1H), 6.52 (s, 1H), 6.94 (d, J=3.2 Hz, 1H), 7.16 (s, 1H), 7.28-7.31 (m, 1H), 7.53 (br s, 1H,), 7.79 (br s, 1H), 8.37 (s, 1H). Mass Spectrum (ESI) m/e=549.0 (M+1).

Provenance & Evidence