Ethyl isocyanate → HCID 57449783, compound

Participants

Reaction Steps

Prepared according to Procedure P using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (50.0 mg, 0.11 mmol) and ethylisocyanate to give 4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)-N-ethylpiperazine-1-carboxamide. 1H NMR (DMSO-d6) δ ppm 1.03 (t, J=6.4 Hz, 3H), 2.08 (br s, 3H), 3.05-3.11 (m, 6H), 3.25 (br s, 4H), 3.44-3.45 (m, 4H), 3.68-3.69 (m, 4H), 6.49 (br s, 1H), 6.59-6.56 (m, 1H), 7.13-7.18 (m, 1H), 7.28-7.30 (m, 1H), 7.53 (s, 1H), 7.78 (s, 1H), 8.36 (s, 1H). Mass Spectrum (ESI) m/e=512.1 (M+1).

Provenance & Evidence