1H-Imidazole-2-carboxylic acid → HCID 59631421, compound

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Reaction Steps

Prepared according to Procedure Q using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (40.0 mg, 0.09 mmol) and 1H-imidazole-2-carboxylic acid to give (4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)(1H-imidazol-2-yl)methanone. 1H NMR (DMSO-d6) δ ppm 2.13 (br s, 3H), 3.06 (br s, 4H), 3.33-3.39 (m, 4H), 3.69 (br s, 4H), 3.84-3.85 (m, 2H), 4.66-4.69 (m, 2H), 6.50 (br s, 1H), 7.11-7.16 (m, 1H), 7.18-7.20 (m, 1H), 7.28-7.31 (m, 2H), 7.54 (br s, 1H), 7.79 (s, 1H), 8.38 (br s, 1H), 12.96 (s, 1H). Mass Spectrum (ESI) m/e=534.9 (M+1).

Provenance & Evidence