1,3-Oxazole-4-carboxylic acid → HCID 59631521, compound

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Reaction Steps

Prepared according to Procedure Q using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (40.0 mg, 0.09 mmol) and oxazole-4-carboxylic acid to give (4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)(oxazol-4-yl)methanone. 1H NMR (DMSO-d6) δ ppm 2.11 (br s, 3H), 3.05 (t, J=4.4 Hz, 4H), 3.32-3.37 (m, 4H), 3.69 (t, J=4.4 Hz, 4H), 3.80 (br s, 2H), 4.00-4.07 (m, 2H), 6.51 (s, 1H), 7.11-7.16 (m, 1H), 7.27-7.32 (m, 1H), 7.53 (s, 1H), 7.78 (s, 1H), 8.36 (s, 1H), 8.54 (s, 1H), 8.62 (s, 1H). Mass Spectrum (ESI) m/e=536.0 (M+1).

Provenance & Evidence