Nicotinic Acid → HCID 59631374, compound

Participants

Reaction Steps

Prepared according to Procedure Q using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (40.0 mg, 0.09 mmol) and nicotinic acid to give (4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)piperazin-1-yl)(pyridin-3-yl)methanone. 1H NMR (DMSO-d6) δ ppm 2.10 (s, 3H), 3.05 (br s, 4H), 3.32-3.40 (br s, 4H), 3.54 (br s, 2H), 3.68 (br s, 4H), 3.84 (br s, 2H), 6.50 (br s, 1H), 7.16 (br s, 1H), 7.28 (br s, 1H), 7.56 (br s, 2H), 7.78 (s, 1H), 7.90 (d, J=7.6 Hz, 1H), 8.36 (s, 1H), 8.67 (s, 2H). Mass Spectrum (ESI) m/e=545.7 (M+1).

Provenance & Evidence