3,3,3-Trifluoropropanal → HCID 59631219, compound

Participants

Reaction Steps

Prepared according to Procedure L using 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(piperazin-1-yl)quinolin-4-amine (25.0 mg, 0.056 mmol) and 3,3,3-trifluoropropanal to give 5,7-difluoro-3-methyl-N-(5-morpholinopyridin-3-yl)-2-(4-(3,3,3-trifluoropropyl)piperazin-1-yl)quinolin-4-amine. 1H NMR (DMSO-d6) δ ppm 2.07 (br s, 3H), 2.50 (m(buried), 2H), 2.60 (br s, 6H), 3.04 (br s, 4H), 3.29-3.31 (m, 4H), 3.69 (br s, 4H), 6.49 (s, 1H), 7.10-7.16 (m, 1H), 7.26-7.28 (m, 1H), 7.51 (s, 1H), 7.77 (s, 1H), 8.32 (s, 1H). Mass Spectrum (ESI) m/e=537.1 (M+1).

Provenance & Evidence