5-Morpholinopyridin-3-amine → HCID 57449770, compound

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Reaction Steps

Prepared according to Procedure H using 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)-4,4-dimethylpyrrolidin-2-one (150 mg, 0.46 mmol) and 5-morpholinopyridin-3-amine in toluene to give 1-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)-4,4-dimethylpyrrolidin-2-one. 1H NMR (CDCl3) δ ppm 8.11 (1H, d, J=1.8 Hz), 8.02 (1H, d, J=9.2 Hz), 7.83 (1H, d, J=2.2 Hz), 7.45 (1H, dd, J=9.3, 1.1 Hz), 7.02 (1H, ddd, J=13.3, 8.6, 2.5 Hz), 6.82 (1H, t, J=2.2 Hz), 3.91 (2H, br. s.), 3.71-3.85 (4H, m), 3.25-3.39 (4H, m), 2.44 (2H, s), 2.09 (3H, s), 1.34 (6H, s). Mass Spectrum (ESI) m/e=468.3 (M+1).

Provenance & Evidence