Methyl Isocyanate → HCID 67508405, compound

Participants

Reaction Steps

Prepared according to Procedure N using (R)-5,7-difluoro-3-methyl-2-(3-methylpiperazin-1-yl)-N-(5-morpholinopyridin-3-yl)quinolin-4-amine (50.0 mg, 0.11 mmol) and methylisocyanate to give (R)-4-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)-N,2-dimethylpiperazine-1-carboxamide. 1H NMR (CDCl3) δ ppm 7.93 (1H, d, J=2.5 Hz), 7.68 (1H, d, J=2.3 Hz), 7.27-7.33 (1H, m), 6.92 (1H, d, J=12.7 Hz), 6.79 (1H, ddd, J=13.8, 8.8, 2.6 Hz), 6.58 (1H, t, J=2.3 Hz), 4.58 (1H, q, J=4.3 Hz), 4.16-4.29 (1H, m), 3.78-3.92 (5H, m), 3.68-3.78 (1H, m), 3.54-3.64 (1H, m), 3.36 (1H, td, J=12.4, 3.3 Hz), 3.11-3.25 (5H, m), 2.95 (1H, td, J=12.4, 3.4 Hz), 2.85 (3H, d, J=4.5 Hz), 2.09 (3H, s), 1.30 (3H, d, J=6.7 Hz). Mass Spectrum (ESI) m/e=512.3 (M+1).

Provenance & Evidence