5-Morpholinopyridin-3-amine → HCID 59631026, compound

Participants

Reaction Steps

Prepared according to Procedure H using (S)-tert-butyl 1-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)pyrrolidine-2-carboxylate (260 mg, 0.68 mmol) and 5-morpholinopyridin-3-amine in toluene to give (S)-tert-butyl 1-(5,7-difluoro-3-methyl-4-(5-morpholinopyridin-3-ylamino)quinolin-2-yl)pyrrolidine-2-carboxylate. 1H NMR (CDCl3) δ ppm 7.80 (1H, d, J=2.2 Hz), 7.65-7.75 (2H, m), 7.07-7.17 (1H, m), 6.90 (1H, br. s.), 6.60 (1H, ddd, J=13.1, 8.8, 2.5 Hz), 4.71 (1H, t, J=7.0 Hz), 3.83-3.94 (1H, m), 3.77-3.83 (4H, m), 3.67-3.77 (1H, m), 3.15-3.26 (4H, m), 2.28-2.43 (1H, m), 2.21 (3H, s), 2.08-2.19 (1H, m), 1.90-2.06 (2H, m), 1.45 (9H, s). Mass Spectrum (ESI) m/e=526.3 (M+1).

Provenance & Evidence