4-Amino-2-chlorobenzonitrile → 4-amino-2-chloro-5-iodobenzonitrile

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-amino-2-chlorobenzonitrile (5.0 g, 33 mmol) and N-iodosuccinimide (8.4 g, 37 mmol) in Acetic Acid (35 mL) was stirred at 23° C. After 18 h, the solid was collected by filtration then purified on silica gel (0-20% EtOAc in hexanes) to afford a pale brown solid as 4-amino-2-chloro-5-iodobenzonitrile. 1H NMR (500 MHz, CDCl3) δ ppm 7.87 (1H, s), 6.77 (1H, s), 4.72 (2H, br. s.)

Provenance & Evidence