Morpholine → HCID 67508051, compound

Participants

Reaction Conditions

Reaction Steps

4-Amino-2-chloro-5-iodobenzonitrile (0.60 g, 2.1 mmol) and morpholine (2.0 mL, 23 mmol) were added to a microwave vial and heated in the microwave to 200° C. After 60 minutes, the residue was concd then purified on silica gel (0-40% EtOAc in hexanes) to yield a white solid as 4-amino-5-iodo-2-morpholinobenzonitrile. Mass Spectrum (pos.) m/e: 330.0 (M+H)+. 4-amino-2-morpholinobenzonitrile was also isolated. 1H NMR (500 MHz, CDCl3) δ ppm 7.35 (1H, d, J=8.3 Hz), 6.28 (1H, dd, J=8.4, 2.1 Hz), 6.20 (1H, d, J=2.0 Hz), 4.14 (2H, br. s.), 3.95 (4H, m), 3.24 (4H, m). Mass Spectrum (pos.) m/e: 204.1 (M+H)+.

Provenance & Evidence