4-[5-(Tributylstannyl)pyridin-2-yl]morpholine → HCID 59631102, compound

HRID 1431717Notes

Reaction equation

HRID 1431717 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.C([Sn](CCCC)(CCCC)[C:21]1[CH:22]=[CH:23][C:24]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[N:25][CH:26]=1)CCC>C1(C)C=CC=CC=1>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([C:21]2[CH:22]=[CH:23][C:24]([N:27]3[CH2:28][CH2:29][O:30][CH2:31][CH2:32]3)=[N:25][CH:26]=2)[C:11]=1[CH3:12]

Participants

4

Reactant 2

HCID 164271164-[5-(Tributylstannyl)pyridin-2-yl]morpholineHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 59631102HCID 59631102, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

The Stille coupled product was prepared according to Procedure E using 2,4-dichloro-5,7-difluoro-3-methylquinoline (0.30 g, 1.21 mmol), 4-(5-(tributylstannyl)-pyridin-2-yl)morpholine (0.66 g, 1.45 mmol), palladium tetrakistriphenylphosphine (0.140 g, 0.12 mmol) in toluene (2 mL) to give 4-(5-(4-chloro-5,7-difluoro-3-methylquinolin-2-yl)pyridin-2-yl)morpholine as a white solid. Mass Spectrum (ESI) m/e=376.0 (M+1).

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-f275e941e6ca47f7b6172e3f6d7cd757
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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