2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 59631056, compound

Participants

Reaction Steps

Prepared according to Procedure Y using 3-amino-N,N-dimethyl-5-morpholinobenzamide (0.046 g, 0.183 mmol), 4-chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)-quinoline (0.050 g, 0.183 mmol), sodium tert-butoxide (0.035 g, 0.367 mmol), XPhos (8.7 mg, 0.018 mmol), XPhos precatalyst (CAS 1028206-56-5; 0.012 g, 0.018 mmol), and toluene (1.0 mL) to afford 3-((7-fluoro-3-methyl-2-(2-pyridinyl)-4-quinolinyl)amino)-N,N-dimethyl-5-(4-morpholinyl)benzamide as a yellow amorphous solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.66-8.71 (1H, m), 8.60 (1H, s), 8.09 (1H, dd, J=9.4, 6.3 Hz), 7.99 (1H, td, J=7.7, 1.8 Hz), 7.87 (1H, dt, J=7.8, 1.2 Hz), 7.71-7.77 (1H, m), 7.45-7.52 (2H, m), 6.41-6.46 (1H, m), 6.35-6.41 (1H, m), 5.95-5.98 (1H, m), 3.68-3.73 (4H, m), 3.04-3.11 (4H, m), 2.82-2.91 (6H, m), 2.21 (3H, s). Mass Spectrum (ESI) m/e=486.2 (M+1).

Provenance & Evidence