2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 59631286, compound

Participants

Reaction Steps

Prepared according to Procedure N using 3-(5-methyl-1,3,4-oxadiazol-2-yl)-5-morpholinoaniline (0.034 g, 0.131 mmol), 4-chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline (0.036 g, 0.131 mmol), sodium tert-butoxide (0.031 g, 0.327 mmol), XPhos precatalyst (CAS 1028206-56-5; 8.79 mg, 0.013 mmol), XPhos (6.23 mg, 0.013 mmol), and toluene (0.7 mL) to afford 7-fluoro-3-methyl-N-(3-(5-methyl-1,3,4-oxadiazol-2-yl)-5-(4-morpholinyl)phenyl)-2-(2-pyridinyl)-4-quinolinamine as a yellow amorphous solid. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.79 (1H, s), 8.68-8.71 (1H, m), 8.07-8.15 (1H, m), 8.00 (1H, dd, J=7.6, 2.0 Hz), 7.88-7.91 (1H, m), 7.77 (1H, dd, J=10.3, 2.6 Hz), 7.48-7.54 (2H, m), 6.96 (1H, t, J=1.9 Hz), 6.72 (1H, t, J=1.7 Hz), 6.51 (1H, t, J=2.2 Hz), 3.70-3.74 (4H, m), 3.07-3.14 (4H, m), 2.52 (3H, s), 2.23 (3H, s). Mass Spectrum (ESI) m/e=497.1 (M+1).

Provenance & Evidence