HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 59631305, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl | HCID 11155794 | — |
| Reactant | Sodium t-butoxide | HCID 23676156 | — |
| Reactant | 4-Chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline | HCID 59631075 | — |
| Reactant | HCID 59631494 | HCID 59631494 | — |
| Catalyst | XPhos Palladacycle | HCID 54751079 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 59631305 | HCID 59631305 | — |
Reaction Steps
Prepared according to Procedure Y using 4-chloro-7-fluoro-3-methyl-2-(pyridin-2-yl)quinoline (0.300 g, 1.100 mmol), methyl 3-amino-5-morpholinobenzoate (0.260 g, 1.100 mmol), XPhos precatalyst (CAS 1028206-56-5; 0.074 g, 0.110 mmol), XPhos (0.052 g, 0.110 mmol), sodium tert-butoxide (0.26 g, 2.75 mmol), and toluene (2.2 mL). Purification by column chromatography (silica; 0-90% EtOAc in hexanes) afforded methyl 3-(7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-ylamino)-5-morpholinobenzoate as a yellow amorphous solid. Mass Spectrum (ESI) m/e=473.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08940724B2 |
| Source dataset | uspto-grants-2015_01 |
| ORD ID | ord-bee71fa54c214431bdd0db6e79d23826 |
| Source note | uspto-grants-2015_01 |