Trifluoroacetic acid → HCID 59631180, compound

Participants

Reaction Steps

A solution of 7-fluoro-N-(4-methoxybenzyl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine (0.900 g, 2.410 mmol), trifluoroacetic acid (2.8 mL, 36.2 mmol), and DCM (4 mL) was stirred at 23° C. for 1 hour. Upon completion, the reaction was concd, and the resulting residue was partitioned between EtOAc and 1 N HCl. The aqueous layer was then basified, and the product extracted twice with EtOAc. The combined organics were dried over magnesium sulfate and concd, affording 7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine as a beige amorphous solid. Mass Spectrum (ESI) m/e=254.2 (M+1).

Provenance & Evidence